Recombinant Rat Anti-NGF Antibody (αD11) (CAT#: PABX-146)
Anti-NGF antibody is a Rat antibody of IgG class that binds to an NGF. The rat monoclonal antibody (mAb) has been shown to bind to NGF with nanomolar affinity and with high specificity and to effectively neutralize its in vitro and in vivo biological functions.
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Figure 1 IP and WB of transgenic and wild-type mice.
IP and WB of cortex extracts from male(M) and female(F) TgProNGF#72 and wild-type (WT) mice. IP on extracts from cortex(CTX) with anti-NGF aD11 antibody, followed by WB with anti-NGF or anti-proNGF antibody, as described in Tiveron et al.(2013). Are presentative WB probed with anti-proNGF(PAb Alomone),(top)or anti-NGFM20 (Santa Cruz)(bottom) is shown. TgproNGF#72 and wild type mice,male and female,were analyzed.
Malerba, F., Paoletti, F., & Cattaneo, A. (2016). NGF and proNGF reciprocal interference in immunoassays: open questions, criticalities, and ways forward. Frontiers in molecular neuroscience, 9, 63.
Figure 2 EmaxNGF Promega:NGFS tandard curves.
NGF standard curves carried out by usingr at mAb Promega(triangles) and mAb aD11(Cattaneoetal.,1988) (squares) as primary antibody.
Malerba, F., Paoletti, F., & Cattaneo, A. (2016). NGF and proNGF reciprocal interference in immunoassays: open questions, criticalities, and ways forward. Frontiers in molecular neuroscience, 9, 63.
Figure 3 SPR analysis-calibration curve sobtained with proNGF and NG Fover the panel of different antibodies.
Different pro NGF concentrations tested on anti-NGFmAb aD11. ConcentrationsinnM(fromtop): 500,333,222,148,98, 65,33,16,8,4,2,1,0.5.
Malerba, F., Paoletti, F., & Cattaneo, A. (2016). NGF and proNGF reciprocal interference in immunoassays: open questions, criticalities, and ways forward. Frontiers in molecular neuroscience, 9, 63.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Rat
- Derivation
- Rat
- Type
- IgG
- Specificity
- Tested positive against native NGF
- Clone
- αD11
- Applications
- Neut (assay dependent)
FuncS (assay dependent)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-111 | Anti-Human NGF Recombinant Antibody (TAB-111) | ELISA, FuncS, Inhib | IgG2 |
| TAB-686CL | Anti-Human NGF Therapeutical Antibody (TAB-686CL) | FuncS | Antibody |
| TAB-501MZ | Anti-Human NGF Recombinant Antibody (TAB-501MZ) | ELISA | Humanized antibody |
| TAB-501MZ-S(P) | Anti-Human NGF Recombinant Antibody scFv Fragment (TAB-501MZ-S(P)) | ELISA, IRMA, RIA, IHC | Humanized antibody |
| TAB-501MZ-F(E) | Anti-Human NGF Recombinant Antibody Fab Fragment (TAB-501MZ-F(E)) | ELISA, IRMA, RIA, IHC | Humanized antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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